Yet, another review of ADT side effects

Adverse effects of androgen deprivation therapy in prostate cancer and their management. By Rhee et al. 2014


Key sentence from the paper: “The general principle of managing adverse effects of long term ADT is: 1) to recognize that they are almost universal; 2) to discuss the potential complications with patients and partners prior to initiating the treatment; and 3) to proactively prevent, reduce and address the problems.


For the full abstract, see:


Commentary: Reviews of ADT side effects and their managements come out almost monthly and sometimes even weekly. There is nothing particularly new in this review but it is well-written and easy to read. It also gives an Australian perspective on ADT.

 Neither the side effects mentioned nor the treatment options for them discussed here are as comprehensive as in the ADT Book. In term of hot flash management, one of the two most bothersome side effects for patients, virtually all pharmaceutical treatments are off-label uses in Australia. What is missing from the list of options is topical estradiol.


Rhee H, Gunter JH, Heathcote P, Ho K, Stricker P, Corcoran NM, Nelson CC. 2014. Adverse Effects of Androgen Deprivation Therapy in Prostate Cancer and Their Management. BJU International 18 November 2014 [Epub ahead of print].