The elevated stroke risk was present whether ADT was achieved with LHRH drugs alone or in combination with anti-androgen rugs like Casodex. ADT. It also occurred in patients who are androgen deprived because of surgical castration. The risk, however, was not seen in patients treated with only an anti-androgen alone. These results come from an analysis of six studies involving over 160 thousand men.
Meng F, Zhu S, Zhao J, Vados L, Wang L, Zhao Y, Zhao D, Niu Y. 2016. Stroke related to androgen deprivation therapy for prostate cancer: a meta-analysis and systematic review. BMC Cancer 16(1):180. www.ncbi.nlm.nih.gov/pubmed/26940836