Does ADT increase the risk of depression?

Back to the SEER database… The data reviewed here were taken from records on 78,552 prostate cancer patients. Yes, ADT increases the risk of depression by, on average, 23%. 


Dinh KT, Reznor G, Muralidhar V, Mahal BA, Nezolosky MD, Choueiri TK, Hoffman KE, Hu JC, Sweeney CJ, Trinh QD, Nguyen PL. 2016. Association of Androgen Deprivation Therapy With Depression in Localized Prostate Cancer. J Clin Oncol 34(16):1905-1912.