Does ADT increase the risk of dementia?

The controversy continues. Over the last two years, we discussed several papers suggesting that ADT can lead to cognitive impairments. The good news from this study says that ADT does not increase the risk of dementia. This study is from a review of records in a Taiwanese database. It involved 775 patients on ADT and 559 patients not on ADT. The authors appropriately point out that it would be premature to conclude that what is true for Taiwanese men is true for men elsewhere in the world.


Wu CT, Yang YH, Chen PC, Chen MF, Chen WC. 2015. Androgen deprivation increases the risk of fracture in prostate cancer patients: a population-based study in Chinese patients. Osteoporos Int 26(9):2281-2290.