When given a choice, only 14% of men on ADT ≥1 year chose having an orchiectomy every though they are candidates for life long ADT. Quality of life outcomes showed no difference between orchiectomy and continuing standard ADT. Notably, decision regret was low among patients who chose the orchiectomy.

Reference: 

Lazarovich, A., Stadler, W. M., Eggener, S., Tremblay, S., Page, A., Diaz, H., ... & Reizine, N. (2025, September). The comeback of orchiectomy in advanced prostate cancer-is that feasible?. In Urologic Oncology: Seminars and Original Investigations. Elsevier.