Key sentence from the paper: “The addition of radiotherapy to ADT for patients with locally advanced prostate cancer significantly improved overall survival and had only modest and transient negative impact on relevant domains of health-related quality of life [outcomes].” 

Key sentence from the paper: “Diabetes mellitus may have a detrimental effect on progression of advanced prostate cancer, particularly in those patients with radiographic evidence of metastases.” 

Key sentence from the paper: “Increased age, greater comorbidity, being in a racial/ethnic minority, high primary care utilization in the prior year and receiving a radiation oncology consultation before treatment were associated with increased odds of gonadotropin releasing hormone agonist overuse.” 

Key sentence from the paper: “In terms of adverse effects, including bone loss, cardiovascular risk, and other factors, ADT appeared to be better tolerated in Japanese than Western populations.” 

Key sentence from the paper: “The results [of this study] suggest a 75% increased risk of metabolic syndrome and a 36% increased risk of diabetes following ADT for men with prostate cancer.” 

Key sentence from the paper: “A 6-month diet and physical activity intervention can minimize the adverse body composition changes associated with ADT.” 

Key sentence from the paper: “[This study] found no statistically significant difference in the outcome of overall survival, biochemical failure, local progression, distant metastasis or disease-free survival with the addition of chemotherapy using oral etoposide to a regimen of 2 years of androgen suppression + radiation therapy.”

Key sentence from the paper: “[T]here is no increase in the mortality of men treated with [primary androgen deprivation therapy].

Key sentence from the paper: “[O]ur analysis reported a significant increase in cardiac events and hypertension in [metastatic castrate resistant prostate cancer] patients treated with new hormonal therapies.” 

Key sentence from the paper: “ADT with GnRH agonists or orchiectomy increases the risk of fracture in Chinese patients with prostate cancer. However, the magnitude of the increase in risk is seemingly not as large as that in Western populations.”