Key sentence from the paper: “… docetaxel should be considered in routine practice for suitable men with newly diagnosed metastatic disease, and also for selected men with high-risk non-metastatic disease in view of substantial prolongation of [failure-free survival].” 

Key sentence from the paper: “…chronological arguments remain strongest for relating [sleep apnea] to enzalutamide.” 

Key sentence from the paper: “31% of the chemotherapy-naïve patients remained on enzalutamide therapy for >2yr and 17% for >4%. This contrasts with the 2-yr on –treatment rate of 5% for postchemotherapy patients.” 

Key sentence from the paper: “Long-term enzalutamide monotherapy in men with noncastrate [hormone naïve prostate cancer] is associated with large sustained reductions in PSA, signals indicating a favorable tumor response, and favorable safety/tolerability profile.”

Key sentence from the paper: “[men] on ADT experienced greater bother at loss of sexual function than patients not on ADT, suggesting that loss of libido when on ADT does not mitigate the psychological distress associated with loss of erection.” 

Key sentence from the paper: “Both patients and partners report that patients have had significantly worse mood since beginning ADT. Partners reported a larger difference in the patients’ mood than did the patients themselves for all parameters [i.e., depression, anger, fatigue, confusion] except vigor and tension.” 

Key sentence from the paper: “ADT was significantly associated with an increased risk of any fracture and hip fracture requiring hospitalisation.”

Key sentence from the paper: “[a 6-month depot formulation of Lupron] was not inferior to [a 3-month depot formulation of Lupron] for the suppressive effect on serum testosterone level.” 

Key sentence from the paper: “…1-year relative survival ranging from 93% to 96% and 5-year relative survival between 71% and 78%.”

Key sentence from the paper: “We have seen the pendulum of ADT-associated cardiovascular disease swinging back and forth for almost a decade, and until a study is designed to directly answer the question of ADT’s role in cardiovascular disease, the pendulum will keep on swinging.”