Key sentence from the paper: “We… observed a statistically significant increased risk of Alzheimer’s disease with increasing duration of ADT...” 

Key sentence from the paper: “…hormonal therapy was associated with increased risk of myocardial infarction and stroke.” 

Key sentence from the paper: “More than half the patients who received long-term ADT did not experience recovery to normal testosterone levels at 5 years after cessation.” 

Key sentence from the paper: “…it might be time to address whether orchiectomy could be the more appropriate modality [than LHRH agonists like Lupron or Zoladex] for prostate cancer patients requiring androgen deprivation.”

Key sentence from the paper: “At now the most updated international guidelines EAU guide-lines (Heidenreich et al., 2013) underlines that intermittent androgen deprivation therapy should be widely offered to patients with prostate cancer in various clinical settings, in particular those patients who relapse after radiotherapy.” 

Key sentence from the paper: “...elderly men assigned to intermittent ADT had an increased incidence of ischemic and thrombotic events.” 

Key sentence from the paper: “Evidence of increased emotional lability and depressed mood in men who receive ADT…and the risk of depression in the patient’s partner is discussed. The evidence for adverse cognitive effects with ADT is still emerging but suggests that ADT is associated with impairment in multiple cognitive domains.”

Key sentence from the paper: “…[intermittent ADT] produces a longer duration in median time to [castrate resistant prostate cancer] than does [continuous ADT].”

Key sentence from the paper: “Three months or longer exposure to androgen deprivation therapy was associated with reduced cardiorespiratory capacity and resting metabolic rate.”

Key sentence from the paper: “In patients with high-risk prostate cancer, we observed 6 cases (5.4%) of pT0 disease that showed no tumor recurrence during the follow-up… ADT can induce a complete pathological response, and can potentially eradicate advanced prostate cancer.”